Disentangling channel gating mechanisms
Kalienkova et al. report structures of an FMRFamide-gated sodium channel (FaNaC) in several functional states, disentangling how different invertebrate receptors recognize similar neuropeptides.
Kalienkova et al. report structures of an FMRFamide-gated sodium channel (FaNaC) in several functional states, disentangling how different invertebrate receptors recognize similar neuropeptides.
NAD(H) redox homeostasis has a fundamental role in cellular metabolism. We screened for potential modulators of NAD(H) using a genome-scale RNA interference (RNAi) approach combined with SoNar, a high-performance sensor that is sensitive to the redox state of NAD(H). Our analysis identified HES4 as a negative regulator of the NADH/NAD+ ratio that influences pyrimidine biosynthesis and exerts a potent oncogenic effect.