Exercise may exert beneficial effects on cognitive functions and play an important role in the prevention of neurodegenerative diseases. Such effects seem to be mediated by changes in anti-oxidative status, but limited information is available on the nature of molecular pathways supporting the antioxidant effects of exercise in the brain. In this study 3-5-month-old male Wistar albino rats were subjected to three times/week moderate intensity exercise on a rodent treadmill for a period of 6 weeks. The tissue antioxidant activity towards various reactive oxygen species (ROS) was determined in the hippocampus. In addition, to identify the molecular pathways that may be involved in ROS metabolism, the expression of nerve growth factor (NGF) and sirtuins (SIRT1 and SIRT3) were measured. Our results showed a higher antioxidant activity in the hippocampus of physically trained rats compared to sedentary controls. Furthermore, exercise induced an up-regulation of NGF, possibly related to an improved redox balance in the hippocampus. These results suggest that physical exercise might prevent age-induced oxidative damage in the hippocampus.

中文翻译：

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体育锻炼可改善大鼠海马组织的总抗氧化能力和基因表达。

运动可能会对认知功能产生有益影响，并在预防神经退行性疾病中发挥重要作用。这种作用似乎是由抗氧化状态的改变所介导的，但是关于支持脑部运动的抗氧化作用的分子途径的性质的信息很少。在这项研究中，对3-5个月大的雄性Wistar白化病大鼠在啮齿动物跑步机上进行了3次/周的中等强度运动，为期6周。在海马中测定了对各种活性氧（ROS）的组织抗氧化活性。另外，为了鉴定可能参与ROS代谢的分子途径，测量了神经生长因子（NGF）和沉默调节蛋白（SIRT1和SIRT3）的表达。我们的结果表明，与久坐的对照组相比，体育锻炼的大鼠海马中的抗氧化活性更高。此外，运动诱发了NGF的上调，这可能与海马中氧化还原平衡的改善有关。这些结果表明体育锻炼可以预防年龄引起的海马氧化损伤。