The purpose of this study was to test the association between a self-report measure of 24-hour adherence to antihypertensive medication and blood pressure (BP) among African Americans. The primary analysis included 3558 Jackson Heart Study participants taking antihypertensive medication who had adherence data for at least one study examination. Nonadherence was defined by self-report of not taking one or more prescribed antihypertensive medications, identified during pill bottle review, in the past 24 hours. Nonadherence and clinic BP were assessed at Exam 1 (2000-2004), Exam 2 (2005-2008), and Exam 3 (2009-2013). Associations of nonadherence with clinic BP and uncontrolled BP (systolic BP ≥ 140 mm Hg or diastolic BP ≥ 90 mm Hg) were evaluated using unadjusted and adjusted linear and Poisson repeated measures regression models. The prevalence of nonadherence to antihypertensive medications was 25.4% at Exam 1, 28.7% at Exam 2, and 28.5% at Exam 3. Nonadherence was associated with higher systolic BP (3.38 mm Hg) and diastolic BP (1.47 mm Hg) in fully adjusted repeated measures analysis. Nonadherence was also associated with uncontrolled BP (prevalence ratio = 1.26; 95% confidence interval = 1.16-1.37). This new self-report measure may be useful for identifying nonadherence to antihypertensive medication in future epidemiologic studies.

中文翻译：

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在杰克逊心脏研究中，坚持服用降压药以及非裔美国人高血压与血压的关系。

这项研究的目的是检验非裔美国人中24小时坚持服用抗高血压药物的自我报告测量与血压（BP）之间的关联。主要分析包括3558名接受降压药物治疗的杰克逊心脏研究参与者，这些参与者具有至少一项研究检查的依从性数据。不依从性的定义是在过去24小时内自我报告未服用一种或多种处方降压药，这是在药瓶检查期间发现的。在检查1（2000-2004），检查2（2005-2008）和检查3（2009-2013）中评估了不依从性和临床BP。使用未调整和调整后的线性和泊松重复测量回归模型评估了不依从性与临床血压和失控血压（收缩压≥140 mm Hg或舒张压BP≥90 mm Hg）的相关性。在完全调整后，对考试1的不依从性患病率为25.4％，对考试2的不依恋患病率为28.7％，对考试3的不依恋的患病率为28.5％。不依从性与较高的收缩压（3.38 mm Hg）和舒张压（1.47 mm Hg）相关。重复措施分析。不坚持也与血压不受控制有关（患病率= 1.26； 95％置信区间= 1.16-1.37）。这项新的自我报告方法可能有助于在未来的流行病学研究中确定对降压药的依从性。95％置信区间= 1.16-1.37）。这项新的自我报告方法可能有助于在未来的流行病学研究中确定对降压药的依从性。95％置信区间= 1.16-1.37）。这项新的自我报告方法可能有助于在未来的流行病学研究中确定对降压药的依从性。