BACKGROUND Hyaluronic acid (HA) is a polysaccharide present in almost all animal tissues, in which it carries out important biological functions, among them, the protection of the joints by lubricating them and dampening the tension in them. OBJECTIVE This study compares the viscoelastic properties of several commercial preparations of HA, to determine their suitability for use as viscosupplementation therapy in joint pathology (osteoarthritis). METHODS 4 HA hydrogels: Durolane®, Synocrom_Forte_One®, Synvisc_One® and Viscoplus_Matrix® and 4 HA solutions: Ostenil®, Ostenil_Plus®, Viscoplus_Gel® and Orthovisc® were analyzed to compare their viscoelatsic rheological parameters using an oscillatory-rotational rheometer. RESULTS With respect to the 4 HA hydrogels, comparison of crossover frequencies allowed division into two main groups: Synvisc_One® and Viscoplus_Matrix®, with crossover frequencies in the order of magnitude of 10-2 Hz, while Synocrom_Forte_One® and Durolane® showed crossover frequencies on the order of 10-1 Hz. Only one of the 4 HA solutions, Viscoplus_Gel®, showed a crossover frequency on the order of 10-2, whereas Ostenil_Plus® and Orthovisc® showed crossover frequencies on the order of 10-1, and Ostenil® remained as a predominantly viscous fluid for frequencies as high as 4.8 Hz. CONCLUSIONS The viscoelastic properties of the HA preparations can be ordered according to the values of G∗ (the rigidity, or vector sum of the elastic modulus G' and the viscous modulus G'') at both transition points (0.5 and 2.5 Hz) as follows: Viscoplus_Matrix® > Viscoplus_Gel® > Durolane® > Synocrom_Forte_One® > Ostenil_Plus® > Synvisc_One® > Orthovisc® > Ostenil®.

中文翻译：

---

透明质酸的粘弹性的表征。

背景技术透明质酸（HA）是存在于几乎所有动物组织中的多糖，在其中其执行重要的生物学功能，其中包括通过润滑关节和减轻关节中的张力来保护关节。目的本研究比较了几种商业制剂HA的粘弹性，以确定它们在关节病理学（骨关节炎）中用作粘液补充疗法的适用性。方法4种HA凝胶：Durolane®，Synocrom_Forte_One®，Synvisc_One®和Viscoplus_Matrix®以及4种HA溶液：Ostenil®，Ostenil_Plus®，Viscoplus_Gel®和Orthovisc®进行了分析，以使用振荡-旋转流变仪比较它们的粘弹性流变参数。结果关于4种HA水凝胶，交叉频率的比较允许分为两个主要组：Synvisc_One®和Viscoplus_Matrix®的分频频率为10-2 Hz，而Synocrom_Forte_One®和Durolane®的分频频率为10-1 Hz。在4种HA解决方案中，只有Viscoplus_Gel®之一显示出交叉频率为10-2数量级，而Ostenil_Plus®和Orthovisc®显示出交叉频率为10-1数量级，而Ostenil®仍然是主要的粘性流体。频率高达4.8 Hz。结论HA制剂的粘弹性能可以根据两个过渡点（0.5和2.5 Hz）的G ∗值（刚性或弹性模量G'和粘性模量G''的矢量和）进行排序，遵循：Viscoplus_Matrix®>Viscoplus_Gel®>Durolane®>Synocrom_Forte_One®>Ostenil_Plus®>Synvisc_One®>