BACKGROUND Tamarind seed polysaccharide (TSP) is used as a texturizing agent and a thickener in food and pharmaceutical products. There are no publications describing the addition of TSP to intra-articular injection formulations for arthritis. OBJECTIVE The purpose of this study was to investigate the rheology and efficacy of the formulation of TSP with hyaluronic acid (HA) as a new material for injection for arthritis. METHODS We investigated the viscoelastic properties of formulations of HA and TSP as potential lubricants for arthritis, and tested the improvement of right/left paw weight distribution in monosodium iodoacetate-induced arthritis in the rat. RESULTS HA formulations with 3% and 4% TSP showed improved rheological characteristics and were protected against changes induced by heat sterilization. Addition of TSP also reduced pain in the arthritis model, as evidenced by normalization of the distribution of paw weight. CONCLUSIONS TSP is a potential material as a substitute for HA or in combination with HA for intra-articular injection for arthritis.

中文翻译：

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罗望子种子多糖与关节炎的透明质酸制剂的流变性质和功效。

背景技术罗望子种子多糖（TSP）在食品和药品中用作纹理化剂和增稠剂。没有出版物描述在关节炎的关节内注射制剂中添加TSP。目的本研究的目的是研究含透明质酸（HA）的新型TSP制剂的流变学和功效。方法我们研究了HA和TSP作为关节炎潜在润滑剂的制剂的粘弹性，并测试了碘代乙酸钠诱发的大鼠关节炎中左右爪重量分布的改善。结果含3％和4％TSP的HA配方具有改善的流变特性，并能防止因热灭菌引起的变化。TSP的添加还减轻了关节炎模型中的疼痛，如爪重分布的正常化所证明。结论TSP是替代HA或与HA联合用于关节炎的关节内注射的潜在材料。