Abstract The continuous emergence of drug-resistant strains of bacteria poses an urgent risk to human health and dictates the need for new antimicrobials. Along this line, we have been working on developing inhibitors of SecA, a key component of the bacterial Sec-dependent secretion machinery. Herein, we describe the synthesis and antimicrobial evaluation of 6-oxo-1,6-dihydropyrimidine-5-carbonitrile derivatives as potential SecA inhibitors.

中文翻译：

---

作为 SecA 抑制剂的新型 4-oxo-5-cyano thiouracil 衍生物的合成和生物学评价

摘要 耐药细菌菌株的不断出现对人类健康构成了紧迫的风险，并要求对新的抗菌药物的需求。沿着这条路线，我们一直致力于开发 SecA 抑制剂，SecA 是细菌 Sec 依赖性分泌机制的关键组成部分。在此，我们描述了 6-oxo-1,6-dihydropyrimidine-5-carbonitrile 衍生物作为潜在 SecA 抑制剂的合成和抗菌评估。