Abstract Cancer is one of the most common causes of death in the world. Despite the importance of combating cancer in healthcare systems and research centers, toxicity in normal tissues and the low efficiency of anticancer drugs are major problems in chemotherapy. Nowadays the aim of many medical research projects is to discover new safer and more effective anticancer agents. 1,3,4-Thiadiazole compounds are important fragments in medicinal chemistry because of their wide range of biological activities, including anticancer activities. The aim of this study was to determine the capacity of newly synthesized 1,3,4-thiadiazole compounds as chemotherapeutic agents. The structures of the obtained compounds were elucidated using 1H-NMR, 13C-NMR and mass spectrometry. Although the thiadiazole derivatives did not prove to be significantly cytotoxic to the tumour tissue cultures, compound 4i showed activity against the C6 rat brain cancer cell line (IC50 0.097 mM) at the tested concentrations.

中文翻译：

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作为潜在抗癌剂的一系列新噻二唑衍生物的合成和表征

摘要 癌症是世界上最常见的死亡原因之一。尽管在医疗保健系统和研究中心对抗癌症很重要，但正常组织的毒性和抗癌药物的低效率是化疗的主要问题。如今，许多医学研究项目的目标是发现新的更安全、更有效的抗癌药物。1,3,4-噻二唑化合物具有广泛的生物活性，包括抗癌活性，是药物化学中的重要片段。本研究的目的是确定新合成的 1,3,4-噻二唑化合物作为化学治疗剂的能力。使用1H-NMR、13C-NMR和质谱法阐明所得化合物的结构。