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The pond snail Lymnaea stagnalis
EvoDevo ( IF 4.1 ) Pub Date : 2020-12-04 , DOI: 10.1186/s13227-020-00169-4
Reiko Kuroda , Masanori Abe

The freshwater snail Lymnaea stagnalis has a long research history, but only relatively recently has it emerged as an attractive model organism to study molecular mechanisms in the areas of developmental biology and translational medicine such as learning/memory and neurodegenerative diseases. The species has the advantage of being a hermaphrodite and can both cross- and self-mate, which greatly facilitates genetic approaches. The establishment of body-handedness, or chiromorphogenesis, is a major topic of study, since chirality is evident in the shell coiling. Chirality is maternally inherited, and only recently a gene-editing approach identified the actin-related gene Lsdia1 as the key handedness determinant. This short article reviews the natural habitat, life cycle, major research questions and interests, and experimental approaches.

中文翻译:

池塘蜗牛Lymnaea stagnalis

淡水田螺(Lymnaea stagnalis)的研究历史悠久,但直到最近才出现,它是一种有吸引力的模型生物,可用于研究发育生物学和转化医学(例如学习/记忆和神经退行性疾病)领域的分子机制。该物种具有雌雄同体的优势,可以交配和自交,极大地促进了遗传方法的发展。手感的建立或手性形态的形成是研究的主要课题,因为手感在壳卷中很明显。手性是母系遗传的,直到最近,一种基因编辑方法才将肌动蛋白相关基因Lsdia1确定为主要的惯性决定因素。这篇简短的文章回顾了自然栖息地,生命周期,主要研究问题和兴趣以及实验方法。
更新日期:2020-12-04
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