BACKGROUND:Numerous functions of saliva depend on its biophysical properties. Mouth rinses react with saliva and change both their own properties and properties of saliva. OBJECTIVE:The aim of this study was to define the level of mixing of artificial saliva and mouth rinses, define their viscosityand its changes at room and body temperature. METHODS:Artificial saliva, fluoride solutions, chlorhexidine, zinc-hydroxyapatite solution and casein phosphopeptide amorphous calcium phosphate were used. To simulate their mixing, Y-channel PVC chips were used, in two different microfluidics systems. The experiments were recorded with a microscope, then the proportion of mixing was calculated using Matlab. For viscosity measurements rotational viscometer was used. RESULTS:The results show partial mixing of all solutions with artificial saliva. Measurements on a viscometer indicate different viscosity of all used solutions. Viscosity of a mixture of solution and artificial saliva is always in the range of viscosity of the artificial saliva and the solution separately. Moreover, viscosity of all solutions, as well as mixture with artificial saliva, significantly decreases at higher temperature. CONCLUSION:Intraoral administration of mouth rinses results in change of biophysical properties of both saliva and mouth rinses. Those changes can affect preventive and therapeutic effect, and therefore oral health.

中文翻译：

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人工唾液和四种不同漱口水的粘度和混合特性

背景：唾液的许多功能取决于其生物物理特性。漱口水与唾液发生反应并改变其自身的特性和唾液的特性。目的：本研究的目的是确定人工唾液和漱口水的混合水平，确定它们的粘度及其在室温和体温下的变化。方法：采用人工唾液、氟化物溶液、氯己定、锌-羟基磷灰石溶液和酪蛋白磷酸肽无定形磷酸钙溶液。为了模拟它们的混合，在两个不同的微流体系统中使用了 Y 通道 PVC 芯片。用显微镜记录实验，然后用Matlab计算混合比例。对于粘度测量，使用旋转粘度计。结果：结果显示所有溶液与人工唾液部分混合。粘度计上的测量值表明所有使用过的溶液的粘度不同。溶液和人工唾液的混合物的粘度总是在人工唾液和单独溶液的粘度范围内。此外，所有溶液以及与人工唾液的混合物的粘度在较高温度下显着降低。结论：口腔内给予漱口水会导致唾液和漱口水的生物物理特性发生变化。这些变化会影响预防和治疗效果，进而影响口腔健康。以及与人工唾液的混合物，在较高温度下显着降低。结论：口腔内给予漱口水会导致唾液和漱口水的生物物理特性发生变化。这些变化会影响预防和治疗效果，进而影响口腔健康。以及与人工唾液的混合物，在较高温度下显着降低。结论：口腔内给予漱口水会导致唾液和漱口水的生物物理特性发生变化。这些变化会影响预防和治疗效果，进而影响口腔健康。