Abstract

Disruption of element homeostasis may contribute to increased susceptibility of men to cancer development. Whether environmental low-level metal exposure could contribute to the pathogenesis of testicular cancer is unknown. Comparison of the level of 18 elements in whole blood, serum and urine and parameters of oxidative stress/antioxidant status between men with testicular germ cell tumors (TGCT) and healthy men showed significant difference between the groups in most parameters. The results of linear discriminant analysis with a discrimination rate of 96% indicated whole blood Ca, Co, Cu, Fe, K, Mg, Na and Zn, serum Ca, Cu, Na and Ni, and urine Cd, Co, Fe and Mn being the strongest predictors of illness. TGCT patients had a significant increase in serum and blood Cu and decrease in serum Fe and blood Zn with cancer progression. Significantly higher concentrations of Al, As, Pb, and Ni in whole blood/serum of men with TGCT confirm the hypothesis that low-level environmental exposure to these elements may contribute to cancer development. Relationship between elements concentrations and treatment outcomes should be carefully monitored during cancer treatment since high concentrations of commonly used platinum-based chemotherapeutics may additionally disturb the homeostasis of elements.

摘要

元素稳态的破坏可能会导致男性对癌症发展的易感性增加。环境低水平金属暴露是否会导致睾丸癌的发病机制尚不清楚。睾丸生殖细胞肿瘤 (TGCT) 男性与健康男性全血、血清和尿液中 18 种元素的水平以及氧化应激/抗氧化状态参数的比较显示，各组在大多数参数上存在显着差异。线性判别分析结果显示，全血Ca、Co、Cu、Fe、K、Mg、Na、Zn，血清Ca、Cu、Na、Ni，尿Cd、Co、Fe、Mn，判别率为96%是疾病的最强预测因子。TGCT患者的血清和血液Cu显着增加，血清Fe和血液Zn随着癌症进展而降低。TGCT 男性全血/血清中明显更高浓度的 Al、As、Pb 和 Ni 证实了以下假设：低水平环境暴露于这些元素可能会导致癌症发展。在癌症治疗期间应仔细监测元素浓度与治疗结果之间的关系，因为高浓度的常用铂基化疗药物可能会额外干扰元素的稳态。