Cancer Immunotherapy and the Nectin Family,Annual Review of Cancer Biology

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Cancer Immunotherapy and the Nectin Family
Annual Review of Cancer Biology ( IF 7.7 ) Pub Date : 2021-03-04 , DOI: 10.1146/annurev-cancerbio-060920-084910
Robert J. Johnston ₁ , Peter S. Lee ₂ , Pavel Strop ₂ , Mark J. Smyth ₃

Affiliation

It is increasingly clear that the nectin family and its immunoreceptors shape the immune response to cancer through several pathways. Yet, even as antibodies against TIGIT, CD96, and CD112R advance into clinical development, biological and therapeutic questions remain unanswered. Here, we review recent progress, prospects, and challenges to understanding and tapping this family in cancer immunotherapy.

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