Background: Post-surgical adhesion bands (PSABs) are a common complication after abdominal or pelvic surgeries for different reasons like cancer treatment. Despite improvements in surgical techniques and the administration of drugs or the use of physical barriers, there has only been limited improvement in the frequency of postoperative adhesions. Complications of PSAB are pain, infertility, intestinal obstruction, and increased mortality. The most important molecular mechanisms for the development of PSAB are inflammatory response, oxidative stress, and overexpression of pro-fibrotic molecules such as transforming growth factor β. However, questions remain about the pathogenesis of this problem, for example, the causes for individual differences or why certain tissue sites are more prone to post-surgical adhesions. Summary: Addressing the pathological causes of PSAB, the potential role of local angiotensin II/angiotensin II type 1 receptors (AngII/AT1R), may help to prevent this problem. Key Message: The objective of this article was to explore the role of the AngII/AT1R axis potential to induce PSAB and the therapeutic potential of angiotensin receptor blockers in the prevention and treatment of PSAB.
Gastrointest Tumors

中文翻译：

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术后粘连风险与活化的局部血管紧张素 II 1 型受体之间的潜在关联：需要新的治疗策略

背景：术后粘连带 (PSAB) 是腹部或盆腔手术后因癌症治疗等不同原因而发生的常见并发症。尽管手术技术和药物管理或物理屏障的使用有所改进，但术后粘连发生率的改善有限。PSAB的并发症是疼痛、不孕、肠梗阻和死亡率增加。PSAB发展最重要的分子机制是炎症反应、氧化应激和促纤维化分子如转化生长因子β的过度表达。然而，关于这个问题的发病机制仍然存在疑问，例如个体差异的原因或为什么某些组织部位更容易发生术后粘连。总结：针对PSAB的病理原因，局部血管紧张素II/血管紧张素II 1型受体（AngII/AT1R）的潜在作用可能有助于预防这一问题。关键信息：本文的目的是探讨 AngII/AT1R 轴电位诱导 PSAB 的作用以及血管紧张素受体阻滞剂在预防和治疗 PSAB 中的治疗潜力。
胃肠肿瘤