Abstract

This study examined the effects of overnight orthokeratology (OK) on higher-order wavefront aberrations (HOA), axial length elongation, and accommodation. Low to moderate myopic subjects with healthy eyes wore OK lenses nightly for 9 months. Corneal topography wavefront aberrations and accommodation were measured approximately monthly. Linear mixed-effects models were used to examine the association between the change in peripheral corneal parameters relative to the central cornea with HOA, and the association of accommodation and axial length elongation with HOA. Thirty-three participants (mean age 19.61 years) were included. Mean baseline refraction was −2.97 D (range, −1.0 to −5.0 D). The level of spherical aberration (SA) was associated with a change in relative superior-central corneal thickness (β = −0.21, SE = 0.10, p < 0.037) and with the increased difference in superior-central corneal curvature (β = 0.34, SE = 0.15, p = 0.026). The change of coma increased with the change in relative superior corneal curvature (β = 0.84, SE = 0.18, p < 0.001). Axial length elongation was associated with both horizontal coma (β = 0.19, SE = 0.07, p = 0.018) and SA (β = 0.20, SE = 0.07, p = 0.003). While accommodation and axial length were correlated with HOA, axial length elongation was not correlated with accommodation in OK lens wearers.

摘要

这项研究检查了过夜角膜塑形术（OK）对高阶波前像差（HOA），轴向长度伸长和适应性的影响。低至中度近视的受试者，要有健康的眼睛，每晚要戴OK镜片9个月。大约每月测量一次角膜地形波前像差和适应度。线性混合效应模型用于检查HOA与相对于中央角膜的周围角膜参数变化之间的关系，以及HOA与调节和轴向长度伸长率之间的关系。包括33名参与者（平均年龄19.61岁）。平均基线屈光度为-2.97 D（范围-1.0至-5.0 D）。球差（SA）的水平与中央上角膜相对厚度的变化有关（β= -0.21，SE = 0.10，p  <0.037），并且中央上角膜曲率差异增加（β= 0.34，SE = 0.15，p = 0.026）。昏迷的变化随着相对上角膜曲率的变化而增加（β= 0.84，SE = 0.18，p  <0.001）。轴向长度延长与水平昏迷（β= 0.19，SE = 0.07，p = 0.018）和SA（β= 0.20，SE = 0.07，p = 0.003）相关。虽然适应性和轴向长度与HOA相关，但OK眼镜配戴者的轴向长度伸长与适应性不相关。