Synthesis and structural characterization of N(4)-substituted 2-acetylpyridine-N(4)-methyl-3-thiosemicarbazone (L) and its two metal complexes [Cu(L)(OAc)] (1) and [ZnL(OAc)]₂ (2) are reported. Between the two complexes 1 is found to have good anticancer activity against Human lung cancer cell line (A549). Fluorescence microscopy finds the formation of reactive oxygen species on treatment of the cancer cells with 1. The IC₅₀ value of the complex is measured as 0.72 mM which is lower than that of cisplatin against A549.

中文翻译：

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2-乙酰基吡啶-N（4）-甲基-3-硫代半脲（L）及其金属配合物的合成和晶体结构：[Cu（L）（OAc）]的抗癌活性

N（4）-取代的2-乙酰基吡啶-N（4）-甲基-3-硫代半碳酰胺（L）及其两种金属配合物[Cu（L）（OAc）]（1）和[ZnL（OAc）的合成和结构表征）]报告了₂（2）。发现在两种复合物之间1对人肺癌细胞系（A549）具有良好的抗癌活性。荧光显微镜检查发现在用1的癌细胞治疗后会形成活性氧。该复合物的IC ₅₀值为0.72 mM，低于顺铂对A549的IC ₅₀值。