In this issue, Wang et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.201911114) describe a phenomenon in which neuromuscular junction synapse elimination triggers myelination of terminal motor axon branches. They propose a mechanism initiated by synaptic pruning that depends on synaptic activity, cytoskeletal maturation, and the associated anterograde transport of trophic factors including Neuregulin 1-III.

中文翻译：

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在本期中，Wang等。（2021.J.Cell Biol.https：//doi.org/10.1083/jcb.201911114）描述了一种现象，其中神经肌肉接头突触的消除触发末端运动轴突分支的髓鞘化。他们提出了一种由突触修剪启动的机制，该机制取决于突触活性，细胞骨架的成熟以及营养因子（包括神经调节蛋白1-III）的相关顺行转运。