HIV pre-exposure prophylaxis (PrEP) reduces HIV acquisition among adolescent girls and young women (AGYW). Existing evidence suggests that uptake and adherence are low among AGYW and that relationship factors such as gender-based violence (GBV) are important barriers. Through a community-based participatory research (CBPR) process, a youth advisory board (YAB), service providers (SP), and a study team developed the Tu'Washindi na PrEP intervention to support AGYW PrEP use in the context of GBV. The YAB also guided the formative research and interpretation of results. The authors pretested the intervention with SP, AGYW and their partners, and community change agents, and then developed guides for AGYW support clubs, community-based male sensitization sessions, and couples-based events that included formulation of story lines for dramatized PrEP negotiation and information dissemination skills. Stakeholder engagement led to an intervention responsive to AGYW's needs for PrEP support in the context of their relationships, which was evaluated through a 6-month pilot community randomized controlled trial.

中文翻译：

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Tu'Washindi na PrEP：与年轻女性和服务提供者合作，在基于性别的暴力背景下设计一项干预措施，以促进 PrEP 的吸收和坚持。

HIV 暴露前预防 (PrEP) 可减少青春期少女和年轻女性 (AGYW) 的 HIV 感染。现有证据表明，AGYW 的接受度和依从性较低，性别暴力 (GBV) 等关系因素是重要的障碍。通过基于社区的参与式研究 (CBPR) 流程，青年咨询委员会 (YAB)、服务提供者 (SP) 和研究团队开发了 Tu'Washindi na PrEP 干预措施，以支持 AGYW PrEP 在 GBV 背景下的使用。YAB 还指导了形成性研究和结果的解释。作者与 SP、AGYW 及其合作伙伴以及社区变革推动者预先测试了干预措施，然后为 AGYW 支持俱乐部、基于社区的男性宣传会议、和基于夫妻的活动，包括为戏剧化的 PrEP 谈判和信息传播技巧制定故事情节。利益相关者的参与导致了一项干预措施，以响应 AGYW 在其关系背景下对 PrEP 支持的需求，这是通过一项为期 6 个月的试点社区随机对照试验进行评估的。