Abstract

Retinal pigment epithelium and photoreceptor cells are a microenvironment where 90 different peptides are synthesized for transduction, visual cycle, intracellular electron transport chain, and removal of metabolic wastes. Depending on the inheritance pattern, either mutant proteins accumulate inside the cells or the energy cycle is disrupted. Disruption of homeostasis causes the cells to switch to the dormant phase; if the improper conditions last longer, then apoptosis eventually develops resulting in a loss of visual function. In neural tissues, growth factors such as neural growth factor, brain-derived neurotrophic factor, ciliary neurotrophic factor, and insulin-like growth factor are regulatory peptides for intracellular energy cycle and intracellular digestion. In this study, it has been shown histopathologically that autologous growth factors can prevent apoptosis and prevent loss of outer retinal thickness in the retinal degeneration model created with sodium iodate.

摘要

视网膜色素上皮和感光细胞是一个微环境，其中合成了 90 种不同的肽，用于转导、视觉循环、细胞内电子传递链和代谢废物的去除。根据遗传模式，突变蛋白要么在细胞内积累，要么能量循环被破坏。体内平衡的破坏导致细胞切换到休眠期；如果不适当的条件持续更长时间，则最终会发生细胞凋亡，导致视觉功能丧失。在神经组织中，神经生长因子、脑源性神经营养因子、睫状神经营养因子、胰岛素样生长因子等生长因子是细胞内能量循环和细胞内消化的调节肽。在这项研究中，