Abstract

The ubiquitin proteasome system is a key pathway, regulating targeted proteins degradation. A critical step is regulated by E3 ubiquitin ligases, which facilitates the transfer of ubiquitin moieties to substrate proteins, leading proteins degradation via 26S proteasome. However, the number of known ubiquitin dependent processes is still relatively small. Since some stress-related transcription factors are usually essential under stress conditions, while playing negative roles during normal growth, hence their protein levels need to be precisely regulated. However, the mechanism of ubiquitin pathway, regulating transcription factors stability has not been yet summarized. In this review, we attempted to outline the mechanism of E3 ligases dependent transcription factors degradation and discuss the comprehensive role of E3 ligases in phytohormone signaling.

摘要

泛素蛋白酶体系统是调节靶向蛋白质降解的关键途径。一个关键步骤是通过E3泛素连接酶，其促进泛素部分与底物蛋白转移调节，导致蛋白降解经由26S 蛋白酶体。然而，已知的泛素依赖性过程的数量仍然相对较少。由于一些应激相关的转录因子在应激条件下通常是必不可少的，而在正常生长过程中却起负面作用，因此需要精确调节它们的蛋白质水平。然而，泛素途径调控转录因子稳定性的机制尚未总结。在这篇综述中，我们试图概述 E3 连接酶依赖性转录因子降解的机制，并讨论 E3 连接酶在植物激素信号传导中的综合作用。