In evaluating any randomized clinical trial, it is important to determine whether baseline differences between groups could have affected the primary outcome. In our study, muscle insulin sensitivity, which was identical in both groups at baseline, improved after nicotinamide mononucleotide (NMN), not placebo, therapy. Differences in baseline intrahepatic triglyceride content between groups do not negate the effects of NMN observed in muscle.

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对“烟酰胺单核苷酸增加糖尿病前期女性肌肉胰岛素敏感性”评论的回应

在评估任何随机临床试验时，重要的是确定组间的基线差异是否会影响主要结果。在我们的研究中，两组在基线时相同的肌肉胰岛素敏感性在烟酰胺单核苷酸 (NMN) 而非安慰剂治疗后得到改善。组间基线肝内甘油三酯含量的差异并不能否定在肌肉中观察到的 NMN 的影响。