Yoshino et al. (Reports, 11 June 2021, p. 1224) have reported that nicotinamide mononucleotide (NMN) increases muscle insulin sensitivity in prediabetic women. However, the 13 women who received NMN had hepatic lipid content of 6.3 ± 1.2%, whereas the 12 in the placebo group had 14.8 ± 2.0% (P = 0.003). Given that a target of NMN is liver fat clearance, this was not an effectively randomized trial.

中文翻译：

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评论“烟酰胺单核苷酸增加糖尿病前期女性肌肉胰岛素敏感性”

吉野等人。（报告，2021 年 6 月 11 日，第 1224 页）报告说，烟酰胺单核苷酸 (NMN) 会增加糖尿病前期女性的肌肉胰岛素敏感性。然而，接受 NMN 的 13 名女性的肝脏脂质含量为 6.3 ± 1.2%，而安慰剂组的 12 名女性为 14.8 ± 2.0% ( P = 0.003)。鉴于 NMN 的目标是清除肝脏脂肪，这不是一项有效的随机试验。