当前位置: X-MOL 学术Science › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Type 1 diabetes glycemic management: Insulin therapy, glucose monitoring, and automation
Science ( IF 56.9 ) Pub Date : 2021-07-30 , DOI: 10.1126/science.abg4502
Bruce A Perkins 1 , Jennifer L Sherr 2 , Chantal Mathieu 3
Affiliation  

Despite innovations in insulin therapy since its discovery, most patients living with type 1 diabetes do not achieve sufficient glycemic control to prevent complications, and they experience hypoglycemia, weight gain, and major self-care burden. Promising pharmacological advances in insulin therapy include the refinement of extremely rapid insulin analogs, alternate insulin-delivery routes, liver-selective insulins, add-on drugs that enhance insulin effect, and glucose-responsive insulin molecules. The greatest future impact will come from combining these pharmacological solutions with existing automated insulin delivery methods that integrate insulin pumps and glucose sensors. These systems will use algorithms enhanced by machine learning, supplemented by technologies that include activity monitors and sensors for other key metabolites such as ketones. The future challenges facing clinicians and researchers will be those of access and broad clinical implementation.



中文翻译:

1 型糖尿病血糖管理:胰岛素治疗、血糖监测和自动化

尽管胰岛素治疗自发现以来进行了创新,但大多数 1 型糖尿病患者无法实现足够的血糖控制来预防并发症,他们会出现低血糖、体重增加和主要的自我保健负担。胰岛素治疗的药理学进展包括改进极速胰岛素类似物、替代胰岛素递送途径、肝脏选择性胰岛素、增强胰岛素作用的附加药物和葡萄糖反应性胰岛素分子。未来最大的影响将来自将这些药理学解决方案与现有的集成胰岛素泵和葡萄糖传感器的自动化胰岛素输送方法相结合。这些系统将使用机器学习增强的算法,辅以包括活动监测器和其他关键代谢物(如酮)传感器在内的技术。临床医生和研究人员未来面临的挑战将是获取和广泛的临床实施。

更新日期:2021-07-30
down
wechat
bug