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Strategies for durable β cell replacement in type 1 diabetes
Science ( IF 56.9 ) Pub Date : 2021-07-30 , DOI: 10.1126/science.abh1657
Todd M Brusko 1, 2 , Holger A Russ 3 , Cherie L Stabler 4
Affiliation  

Technological advancements in blood glucose monitoring and therapeutic insulin administration have improved the quality of life for people with type 1 diabetes. However, these efforts fall short of replicating the exquisite metabolic control provided by native islets. We examine the integrated advancements in islet cell replacement and immunomodulatory therapies that are coalescing to enable the restoration of endogenous glucose regulation. We highlight advances in stem cell biology and graft site design, which offer innovative sources of cellular material and improved engraftment. We also cover cutting-edge approaches for preventing allograft rejection and recurrent autoimmunity. These insights reflect a growing understanding of type 1 diabetes etiology, β cell biology, and biomaterial design, together highlighting therapeutic opportunities to durably replace the β cells destroyed in type 1 diabetes.



中文翻译:

1型糖尿病中持久β细胞替代的策略

血糖监测和治疗性胰岛素给药的技术进步提高了 1 型糖尿病患者的生活质量。然而,这些努力未能复制天然胰岛提供的精细代谢控制。我们研究了胰岛细胞替代和免疫调节疗法的综合进展,这些疗法正在合并以恢复内源性葡萄糖调节。我们重点介绍了干细胞生物学和移植部位设计方面的进展,它们提供了创新的细胞材料来源和改进的移植。我们还介绍了预防同种异体移植排斥和复发性自身免疫的尖端方法。这些见解反映了对 1 型糖尿病病因、β 细胞生物学和生物材料设计的日益了解,

更新日期:2021-07-30
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