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Vascular rejuvenation is geroprotective
Science ( IF 56.9 ) Pub Date : 2021-07-30 , DOI: 10.1126/science.abj8674
Hellmut G Augustin 1, 2 , Jonathan Kipnis 3
Affiliation  

The scientific perception of blood vessels has changed substantially in recent years. They are no longer considered passive conduits of blood that respond to exogenous cues. Now, the vascular endothelium is considered to act as an instructive gatekeeper to actively control organ function (1). Although mechanisms of local regulation by the vasculature have been identified for most organs and many disease states, including cancer, the study of systemic instructive vascular signaling is still in its infancy. On page 533 of this issue, Grunewald et al. (2) report that low-dose systemic increase of vascular endothelial growth factor–A (VEGFA) in the circulation leads to a notable life span extension in mice. The complex multiorgan rejuvenation phenotype of these mice yields insight into the mechanisms of organism aging and highlights the critical role of the vasculature as a gatekeeper of life span and health span.



中文翻译:

血管再生是老年保护

近年来,对血管的科学认知发生了重大变化。它们不再被视为对外源性线索作出反应的被动血液管道。现在,血管内皮被认为是积极控制器官功能的指导性守门人 ( 1 )。尽管已经为大多数器官和许多疾病状态(包括癌症)确定了脉管系统的局部调节机制,但系统性指导性血管信号传导的研究仍处于起步阶段。在本期第 533 页,Grunewald等人。( 2) 报告说,循环中血管内皮生长因子-A (VEGFA) 的低剂量全身性增加导致小鼠显着延长寿命。这些小鼠复杂的多器官再生表型有助于深入了解机体衰老的机制,并突出了脉管系统作为生命周期和健康周期的看门人的关键作用。

更新日期:2021-07-30
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