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Losing fat through the skin
Science ( IF 56.9 ) Pub Date : 2021-07-30 , DOI: 10.1126/science.abg9079
Marlon R Schneider 1
Affiliation  

Obesity—the excessive accumulation of white adipose tissue (WAT), potentially impairing health—affects millions worldwide and is associated with numerous comorbidities such as type II diabetes and fatty liver disease. The main function of WAT is storage of energy in the form of lipids (fat) and its mobilization as needed. Skin sebaceous glands secrete a lipid-rich product (sebum), which has several functions in maintaining skin integrity, including protection against ultraviolet radiation, elimination of harmful microorganisms (antimicrobial activity), and thermoregulation. Thus, although largely unrelated in structure and function, both WAT and sebaceous glands are stereotyped by intensive lipid metabolism. On page 532 of this issue, Choa et al. (1) show that the cytokine thymic stromal lymphopoietin (TSLP) modulates sebum secretion. Furthermore, they show that if sebum production and release consumes sufficient energy, it can cause significant loss of WAT in mice.



中文翻译:

通过皮肤减脂

肥胖——白色脂肪组织 (WAT) 的过度积累,可能损害健康——影响全球数百万人,并与许多合并症有关,如 II 型糖尿病和脂肪肝。WAT 的主要功能是以脂质(脂肪)的形式储存能量并根据需要进行动员。皮肤皮脂腺分泌一种富含脂质的产品(皮脂),它在保持皮肤完整性方面具有多种功能,包括防止紫外线辐射、消除有害微生物(抗菌活性)和调节体温。因此,尽管在结构和功能上基本上不相关,但 WAT 和皮脂腺都被密集的脂质代谢所定型。在本期第 532 页,Choa等人。( 1) 显示细胞因子胸腺基质淋巴细胞生成素 (TSLP) 调节皮脂分泌。此外,他们表明,如果皮脂的产生和释放消耗了足够的能量,它会导致小鼠体内 WAT 的显着损失。

更新日期:2021-07-30
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