Entrepreneurship is one of the main pillars of growth in any economy. Achieving a high rate of entrepreneurship in a region has become the priority objective of governments and firms. However, in many cases, new firm creation is conditioned by relations or collaboration in innovation with agents from other countries. Previous literature has analyzed the mechanisms that foster entrepreneurship. This paper attempts to shed light on the influence of international patent collaboration (IPC) on entrepreneurial activity at country level taking into account the timing of this relationship. An empirical study is proposed to verify whether IPC leads to greater entrepreneurship and to analyze the gestation period between international patenting actions and firm creation. Using the Generalized Method of Moments, the two hypotheses proposed were tested in a data panel of 30 countries for the period 2005–2017. Results show the influence of IPC in promoting entrepreneurship in the same year, but especially in the following year. The study offers implications for entrepreneurs and public agents. IPC affects the integration and interaction of international agents in a country, favors the production of new knowledge, and increases positive externalities in a territory. All this facilitates the creation of new companies with a high innovative component.

创业精神是任何经济体增长的主要支柱之一。在一个地区实现高创业率已成为政府和企业的优先目标。然而，在许多情况下，新公司的创建取决于与其他国家的代理人的创新关系或合作。以前的文献分析了培养创业精神的机制。本文试图阐明国际专利合作 (IPC) 对国家层面创业活动的影响，同时考虑到这种关系的发生时间。提出了一项实证研究，以验证 IPC 是否会导致更大的创业精神，并分析国际专利行动与企业创建之间的孕育期。使用广义矩法，提出的两个假设在 2005-2017 年期间 30 个国家的数据面板中进行了测试。结果显示IPC对同年创业促进的影响，尤其是次年。该研究为企业家和公共代理人提供了启示。IPC 影响一个国家的国际代理的整合和互动，有利于新知识的生产，并增加一个领土的正外部性。所有这些都有助于创建具有高度创新成分的新公司。IPC 影响一个国家的国际代理的整合和互动，有利于新知识的生产，并增加一个领土的正外部性。所有这些都有助于创建具有高度创新成分的新公司。IPC 影响一个国家的国际代理的整合和互动，有利于新知识的生产，并增加一个领土的正外部性。所有这些都有助于创建具有高度创新成分的新公司。