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Synthesis and spectroscopic investigation of binding of novel Thiazolo [2, 3-a] isoquinoline analog with bovine serum albumin
Indian Journal of Chemistry, Section A ( IF 0.412 ) Pub Date : 2021-08-23
Prasanna B Ranade, Dinesh N Navale, Santosh W Zote, Dnyaneshwar K Kulal, Mohmad V Sheikh, M M V Ramana

A condensation reaction between 1-cyclobutyl-3,4-dihydroisoquinoline and thioglycolic acid has been carried out using DCC yields 10b-cyclobutyl-5,6-dihydro-2H-thiazolo [2, 3-a] isoquinolin-3(10bH)-one [CBIQTGA]. The synthesized compound is characterised by using spectroscopic techniques. The interaction of CBIQTGA with bovine serum albumin has been studied using UV spectroscopy, spectrofluorimetry and circular dichroism techniques.

中文翻译:

新型噻唑并 [2, 3-a] 异喹啉类似物与牛血清白蛋白结合的合成和光谱研究

已使用 DCC 进行 1-环丁基-3,4-二氢异喹啉和巯基乙酸之间的缩合反应,生成 10b-环丁基-5,6-二氢-2H-噻唑并 [2, 3-a] 异喹啉-3(10bH)-一 [CBIQTGA]。通过使用光谱技术表征合成的化合物。已经使用紫外光谱、荧光分光光度法和圆二色性技术研究了 CBIQTGA 与牛血清白蛋白的相互作用。
更新日期:2021-08-23
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