Introduction: The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing and is fueled by a twin-epidemic of obesity and diabetes mellitus in India. The objective of the study was to estimate various noninvasive NAFLD scores (NINS) for the baseline risk-assessment of NAFLD in patients with type 2 diabetes mellitus (T2DM). Methods: An observational, cross-sectional, open label, study of investigator-rated NINS was conducted ensuring adherence to relevant ethical standards. Results: In a 3-month period, 29 patients with T2DM were enrolled (age [mean ± SD]: 55.8 ± 9.72 years; men [n, %]: 18, 62%). One patient (3.45%) by fibrosis-4 index (cutoff for advanced fibrosis ≥2.67) and by AST to platelet ratio index (cutoff ≥0.98); 2 (6.90%) by NAFLD fibrosis score (cutoff ≥0.676); 20 (69%) by body mass index (BMI), AST to ALT ratio, and DM score (BARD; cuff-off ≥2); and 27 (93.10%) by BMI, age, ALT, triglyceride score (cutoff ≥1) indicated high risk for advanced hepatic fibrosis. Only the BARD score (median [min-max]: 3 [1–4]) was elevated above the cutoff values while other scores were below cutoff values. The study failed to demonstrate any correlation between age, gender, anthropometric and metabolic parameters, and NINS. Conclusion: While this study did not demonstrate significant elevation of NINS, scores were found be elevated in some T2DM patients and they may be at high risk of advanced liver fibrosis. Further well-designed studies in this domain are required for early detection, management, and reducing the burden of liver disease in Indian patients with diabetes.
Dubai Diabetes Endocrinol J

中文翻译：

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2型糖尿病患者非酒精性脂肪肝评分基线值及其风险评估

简介：非酒精性脂肪性肝病 (NAFLD) 的患病率正在增加，并受到印度肥胖和糖尿病双重流行病的推动。该研究的目的是估计各种非侵入性 NAFLD 评分 (NINS)，用于 2 型糖尿病 (T2DM) 患者 NAFLD 的基线风险评估。方法：对研究者评定的 NINS 进行了一项观察性、横断面、开放标签的研究，以确保遵守相关的道德标准。结果：在 3 个月的时间里，29 名 T2DM 患者入组（年龄 [平均值 ± SD]：55.8 ± 9.72 岁；男性 [ n, %]: 18, 62%)。一名患者 (3.45%) 通过纤维化 4 指数（晚期纤维化的临界值 ≥ 2.67）和 AST 与血小板比率指数（临界值 ≥ 0.98）；2 (6.90%) NAFLD 纤维化评分（临界值≥0.676）；20 (69%) 按体重指数 (BMI)、AST 与 ALT 比率和 DM 评分（BARD；袖口≥2）；27 (93.10%) 的 BMI、年龄、ALT、甘油三酯评分（临界值≥1）表明晚期肝纤维化的高风险。只有 BARD 分数（中值 [min-max]：3 [1-4]）高于临界值，而其他分数低于临界值。该研究未能证明年龄、性别、人体测量和代谢参数与 NINS 之间存在任何相关性。结论：虽然这项研究没有证明 NINS 显着升高，但发现一些 T2DM 患者的分数升高，并且他们可能处于晚期肝纤维化的高风险中。需要在该领域进行进一步精心设计的研究，以便早期发现、管理和减轻印度糖尿病患者的肝病负担。
迪拜糖尿病内分泌杂志