All the molecules have been designed on the basis of previously reported active pharmacophores via molecular hybridization. A convenient protocol for the preparation of N-((2-(piperazin-1-yl) quinolin-3-yl)methyl)aniline derivatives via mutli-step synthesis has been described. Spectral analysis using Mass, ¹H and ¹³C NMR spectral techniques have been studied in order to confirm the structure of synthesized end molecules. All synthesized compounds have been screened for in vitro antimicrobial, antimalarial and antitubercular activities. Structural activity relationship study (SAR) have also been discussed. Interestingly, target molecules are found to show good to excellent antibacterial, antifungal and antimalarial potency.

中文翻译：

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新型喹啉杂化衍生物的设计与合成及其抗菌、抗疟和抗结核活性

所有分子都是根据先前报道的活性药效团通过分子杂交设计的。描述了通过多步合成制备 N-((2-(哌嗪-1-基) 喹啉-3-基) 甲基) 苯胺衍生物的便捷方案。已经研究了使用质量、¹ H 和¹³ C NMR 光谱技术的光谱分析，以确认合成的末端分子的结构。所有合成的化合物都已经过体外抗微生物、抗疟和抗结核活性的筛选。还讨论了结构活性关系研究 (SAR)。有趣的是，发现目标分子显示出良好的抗菌、抗真菌和抗疟效力。