Incorporation of other hetero-compounds to parent coumarin increases its effectiveness towards its bioactivity. In view of this finding we have synthesized coumarin triazole derivatives. The key synthon used for this reaction pathway are 7-hydroxy-4-methyl-2H-chromen-2-one. This substituted coumarin has been refluxed with 1-bromo-2-chloroethane in presence ofanhydrous K₂CO₃ to afford 7-(2-chloroethoxy)-4-methyl-2H-chromen-2-one, which has been condensed with triazole to yield4-methyl coumarin triazole derivative by optimising solvent/base pair. 4-Methyl group of coumarin triazole derivative has beencondensed with aromatic aldehydes to afford 7-(2-(1H-1,2,4-triazol-1-yl) ethoxy)-4-(styryl/4-substituted styryl)-2H-chromen-2-one 7a-e. All the synthesized products are characterized using IR and, ¹H, ¹³C NMR, mass spectroscopy and elemental analysis.Final synthesized compounds 7a-e have been evaluated for their anti-bacterial and anti-fungal activity.

中文翻译：

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7-(2-(1H-1,2,4-triazol-1-yl)ethoxy)-4-(苯乙烯基/4-取代苯乙烯基)-2H-chromen-2-one的合成及生物活性

将其他杂化合物掺入母体香豆素可提高其生物活性的有效性。鉴于这一发现，我们合成了香豆素三唑衍生物。用于该反应途径的关键合成子是 7-hydroxy-4-methyl-2H-chromen-2-one。该取代香豆素在无水 K ₂ CO ₃存在下与 1-溴-2-氯乙烷回流得到7-(2-氯乙氧基)-4-甲基-2H-chromen-2-one，通过优化溶剂/碱对与三唑缩合得到4-甲基香豆素三唑衍生物。香豆素三唑衍生物的 4-甲基与芳香醛缩合得到 7-(2-(1H-1,2,4-triazol-1-yl) ethoxy)-4-(苯乙烯基/4-取代苯乙烯基)-2H -chromen-2-one 7a-e。所有合成的产物均使用 IR 和¹ H、¹³ C NMR、质谱和元素分析进行表征。最终合成的化合物 7a-e 已经评估了它们的抗菌和抗真菌活性。