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Designing a new vanillin Schiff base (Z)-4-((2-hydroxy-3-methoxy benzylidene)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one: Synthesis, characterization, crystal structure and biological studies
Indian Journal of Chemistry, Section B ( IF 0.456 ) Pub Date : 2021-09-29
Gowri M, Saranya B, Athimoolam S

Novel Schiff base containing antipyrine and o-vanillin has been synthesized and characterized by various physicochemical techniques such as FTIR, UV-Vis, CHN, 1Hand 13C NMR spectral studies. The thermal behavior of the title compound has been examined with Thermogravimetric-Differential thermal analysis (TG-DTA). The structural properties have been further examined by single crystal X-ray diffraction studies. The X-ray diffraction data shows that the compound contains four molecules in the asymmetric unit. Antifungal activity of the compound has been carried out for four different fungi Aspergillus niger, Aspergillus flavus, Aspergillus terrus and Fusarium Sp at three different concentrations, whereas the compound shows significant activity against the fungi Aspergillus niger.

中文翻译:

设计一种新的香草醛席夫碱 (Z)-4-((2-hydroxy-3-methoxy benzylidene)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one:合成、表征、晶体结构和生物学研究

已合成含有安替比林和邻香兰素的新型席夫碱,并通过各种物理化学技术进行表征,例如 FTIR、UV-Vis、CHN、1 Hand 13 C NMR 光谱研究。已用热重-差热分析 (TG-DTA) 检查了标题化合物的热行为。通过单晶 X 射线衍射研究进一步检查了结构特性。X 射线衍射数据表明该化合物在不对称单元中含有四个分子。该化合物在三种不同浓度下对四种不同的真菌黑曲霉、黄曲霉、土曲霉和镰刀菌进行了抗真菌活性,而该化合物对真菌黑曲霉显示出显着的活性。
更新日期:2021-09-29
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