A facile and highly efficient one pot multi-component reaction for the synthesis of 2-thio-5-arylbenzo [4,5]thiazolopyrimido[5,4-d]pyrimidin-4-one derivatives 4 under aqueous medium has been developed. The reaction takes place by condensation of thiobarbituric acids 1, 2-aminobenzothiazole 2 and aldehydes 3 using metal-proline catalyzed domino Knoevenagel, Michael and intramolecular cyclization approach.

中文翻译：

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金属脯氨酸在水中催化合成具有生物活性的 2-thio-5-arylbenzo[4,5]thiazolopyrimido [5,4-d]pyrimidin-4-one 衍生物

已经开发了一种简便高效的一锅多组分反应，用于在水性介质下合成 2-thio-5-arylbenzo [4,5]thiazolopyrimido[5,4-d]pyrimidin-4-one 衍生物 4。该反应通过硫代巴比妥酸 1、2-氨基苯并噻唑 2 和醛 3 使用金属脯氨酸催化的多米诺克诺韦纳格尔、迈克尔和分子内环化方法缩合而发生。