The cetylpyridinium chloride (CPC) has been used as micellar catalyst in three-component one-pot reaction involving thiobarbituric acids, aromatic aldehydes and β-napthol for synthesizing the novel 2-thioxo-benzo[5,6]chromeno[2,3-d]pyrimidin-4-one derivatives in aqueous media. These 2-thioxo-benzo[5,6]chromeno[2,3-d]pyrimidin-4-one derivativeshave been screened for antioxidant and cytotoxic activities. It has been found that 2-thioxo-5-(4-nitrophenyl)-benzo[f]chromeno[2,3-d]pyrimidin-4-one (4a) has shown highest scavenging activity value to reduce DPPH free radicals,which may be due to the presence of nitro group at para-position. Three compounds, 4a, 4b and 4o show significant in vitroantitumor activity. The study of the antioxidant and cytotoxic activities reveal that all the compounds show moderate togood activity indicating that the presence of thiouriedo linkage in the pyrimidine nucleus and the chromeno group attachedto pyrimidene moiety are responsible for these activities.

中文翻译：

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由氯化十六烷基吡啶催化多组分反应衍生的新型 2-硫代-苯并[f]色基[2,3-d]嘧啶-4-酮的合成和抗氧化和细胞毒活性筛选

氯化十六烷基吡啶 (CPC) 已被用作三组分一锅反应的胶束催化剂，涉及硫代巴比妥酸、芳香醛和 β-萘酚，用于合成新型 2-硫代-苯并 [5,6] 色基 [2,3- d]pyrimidin-4-one 衍生物在水性介质中。这些 2-thioxo-benzo[5,6]chromeno[2,3-d]pyrimidin-4-one 衍生物已经过抗氧化和细胞毒活性的筛选。研究发现，2-thioxo-5-(4-nitrophenyl)-benzo[f]chromeno[2,3-d]pyrimidin-4-one (4a)具有最高的清除DPPH自由基的活性值，可能是由于对位存在硝基。三种化合物 4a、4b 和 4o 显示出显着的体外抗肿瘤活性。