One-pot synthesis of novel derivatives of bis-chalcones has been achieved by condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives 3a,b with thioglycolic acid gives compounds 4a,b. This, when reacted with ethyl cyanoacetate in presence of ammonium acetate gives the corresponding cyanopyridine derivatives 5a,b. Furthermore, bis-chalcone 3a,b has been cyclized to pyrazole analogs by using 2,4-dinitrophenylhydrazine to give compounds 7a,b in good yields. All products have been characterized by IR, ¹H and ¹³C NMR, and elemental analysis. The newly synthesised compounds have been screened for anti-bacterial activity

中文翻译：

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双查耳酮的合成和转化为具有预期抗菌活性的双杂环化合物

通过 1,4-二乙酰苯与不同醛在碱性介质中缩合，实现了双查耳酮新型衍生物的一锅法合成。查耳酮衍生物 3a,b 与巯基乙酸反应生成化合物 4a,b。当在乙酸铵存在下与氰基乙酸乙酯反应时，得到相应的氰基吡啶衍生物5a，b。此外，双查耳酮 3a,b 已通过使用 2,4-二硝基苯肼环化为吡唑类似物，以良好的产率得到化合物 7a,b。所有产品均已通过 IR、¹ H 和¹³ C NMR 以及元素分析进行表征。新合成的化合物已经过抗菌活性筛选