In the present investigation, a series of novel (Z)-5-((5-chloro-1H-indol-3-yl)methylene)thiazolidine-2,4-dione analogues have been designed and synthesized in good yields with the objective of selective N-alkylation at thiazolidine 2,4-dione ring in competence with indole ring under basic conditions in the presence of aprotic solvent dimethylformamide (DMF). The newly synthesized compounds have been characterized by spectral data (IR, ¹H and ¹³C NMR, NOE, NOESY, ¹H-¹H-COSY and LC-MS). Further, molecular docking and ADME studies have revealed that the newly synthesized compounds have very good docking score against antidiabetic and anti-inflammation activities (PPARy and COX-2) as compared with standard rosiglitazone.

中文翻译：

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(Z)-5-((5-chloro-1H-indol-3-yl)methylene)thiazolidine-2,4-dione 类似物的选择性 N-烷基化及其分子对接研究的合成和结构确认

在本研究中，设计并合成了一系列新的 (Z)-5-((5-chloro-1H-indol-3-yl)methylene)thiazolidine-2,4-dione 类似物，目标是在非质子溶剂二甲基甲酰胺 (DMF) 存在下，在碱性条件下，噻唑烷 2,4-二酮环与吲哚环选择性 N-烷基化。新合成的化合物已通过光谱数据（IR、¹ H 和¹³ C NMR、NOE、NOESY、¹ H- ¹ H-COSY 和 LC-MS）表征。此外，分子对接和 ADME 研究表明，与标准罗格列酮相比，新合成的化合物在抗糖尿病和抗炎活性（PPARγ 和 COX-2）方面具有非常好的对接评分。