One-pot multicomponent reaction between aromatic aldehyde, hydroxylamine hydrochloride and ethyl acetoacetate/ methyl acetoacetate for the synthesis of isoxazoles derivatives by employing tomato fruit extract as a catalytic medium has been developed. Tomato fruit extract was found to be a favorable catalytic medium for the synthesis of titled compounds. Mild reaction condition, ease of separation, moderate to high yield of the product, and short reaction time makes this method more attractive over earlier reported methods for the synthesis of isoxazoles derivatives.

中文翻译：

---

番茄果实提取物：合成异恶唑衍生物的环境友好型催化介质

以番茄果实提取物为催化介质，芳香醛、盐酸羟胺和乙酰乙酸乙酯/乙酰乙酸乙酯一锅多组分反应合成异恶唑衍生物。发现番茄果实提取物是合成标题化合物的有利催化介质。温和的反应条件、易于分离、产物的中等至高产率和较短的反应时间使该方法比早期报道的合成异恶唑衍生物的方法更具吸引力。