ABSTRACT

Objective

To investigate the expression of complement system’s activation factors in patients with HELLP syndrome.

Methods

A case–control study was performed. Sixteen HELLP syndrome patients, 32 severe preeclampsia patients, and 48 normal pregnancy women were involved in this studyELISA was used to test C1q, C4d, MBL, Bb, C3a, C5a, sC5b-9, s-Endoglin, and sflt-1 in the plasma.

Results

The levels of C5a (P < 0.01) and sC5b-9 (P = 0.014) in HELLP syndrome were higher than those in severe preeclampsia patients.

Conclusions

The abnormal activation of the complement system is more significant in the pathogenesis of HELLP syndrome than in severe preeclampsia.

中文翻译：

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HELLP综合征补体系统失调

摘要

客观的

研究HELLP综合征患者补体系统激活因子的表达情况。

方法

进行了病例对照研究。16 名 HELLP 综合征患者、32 名严重先兆子痫患者和 48 名正常妊娠妇女参与本研究，ELISA 用于检测 C1q、C4d、MBL、Bb、C3a、C5a、sC5b-9、s-Endoglin 和 sflt-1等离子体。

结果

HELLP综合征患者C5a（P < 0.01）和sC5b-9（P = 0.014）水平高于重度子痫前期患者。

结论

补体系统的异常激活在 HELLP 综合征的发病机制中比在严重的先兆子痫中更为显着。