Objectives: The growing prevalence of obesity rates worldwide is associated with an upsurge in its comorbidities, particularly type 2 diabetes mellitus (T2DM). Bariatric surgery is a proven treatment modality for producing sustained weight loss and resolution of associated T2DM providing marked improvement in quality of life with rapid recovery. This study aims to investigate the effects of laparoscopic sleeve gastrectomy (LSG), Roux-en-Y gastric bypass (RYGB), and mini-gastric bypass (MGB) on obese patients suffering from T2DM in the Indian population and their long-term association with regard to diabetes remission, resolution of comorbidities, and percentage EWL. Methods: Retrospective data of obese patients with T2DM (preoperative BMI 45.37 ± 8.1) who underwent bariatric surgery (RYGB, LSG, and MGB) were analyzed in this study over a period of 9 years. The mean follow-up period was 2.2 years. Following surgery, the clinical outcome on BMI, resolution of percentage weight loss, and T2DM were studied. The predictive factors of diabetic remission after surgery were determined. Student’s t test and ANOVA and McNemar’s test were applied. Results: Out of a total of 274 patients, complete remission of T2DM was achieved in 52.9% (n = 145) with mean fasting blood glucose and glycated hemoglobin values being 6.1 ± 0.769 (p = 0.00) at 1 year after surgery. The independent predictive factors of remission were age, gender, BMI, preoperative comorbidities, and % EWL. Gender had no correlation with the chance of achieving disease remission. Conclusion: Based on our results, bariatric surgery proves to be a successful treatment option resulting in sustained weight loss in obese patients suffering from T2DM. It is found to be beneficial for the long-term resolution of T2DM and improving comorbidities such as hypertension and dyslipidemia. The outcome of the different surgical methods is found to be similar for all patients irrespective of the independent predictors of complete remission.
Dubai Diabetes Endocrinol J

中文翻译：

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在印度人群中评估减肥手术对减肥和糖尿病缓解的影响

目标：全球肥胖率的日益流行与其合并症的激增有关，尤其是 2 型糖尿病 (T2DM)。减肥手术是一种经过验证的治疗方式，可产生持续的体重减轻和相关 T2DM 的消退，显着改善生活质量并快速恢复。本研究旨在探讨腹腔镜袖状胃切除术 (LSG)、Roux-en-Y 胃绕道术 (RYGB) 和微型胃绕道术 (MGB) 对印度人群中患有 T2DM 的肥胖患者的影响及其长期关联。关于糖尿病缓解、合并症的解决和 EWL 百分比。方法：本研究对接受减肥手术（RYGB、LSG 和 MGB）的 T2DM 肥胖患者（术前 BMI 45.37 ± 8.1）的回顾性数据进行了 9 年的分析。平均随访时间为 2.2 年。手术后，研究了 BMI、体重减轻百分比和 T2DM 的临床结果。确定手术后糖尿病缓解的预测因素。应用了Student's t检验以及ANOVA 和McNemar's 检验。结果：在总共 274 名患者中，52.9% ( n = 145)的 T2DM 完全缓解，平均空腹血糖和糖化血红蛋白值为 6.1 ± 0.769 ( p= 0.00) 术后 1 年。缓解的独立预测因素是年龄、性别、BMI、术前合并症和%EWL。性别与疾病缓解的机会无关。结论：根据我们的结果，减肥手术被证明是一种成功的治疗选择，可导致患有 T2DM 的肥胖患者持续减轻体重。它被发现有利于 T2DM 的长期消退和改善合并症，如高血压和血脂异常。无论完全缓解的独立预测因素如何，不同手术方法的结果对于所有患者都是相似的。
迪拜糖尿病内分泌杂志