A new series of benzothiazole linked isoxazole Schiff base derivatives have been prepared and characterized by suitable spectroscopic methods via 1H and 13C NMR, ESI-MS and IR spectra. These compounds have been further screened for their antimicrobial activity against a panel of microorganisms. Among them, compounds 12d, 12g and 12l demonstrate promising antimicrobial activity against all the tested strains with MIC values ranging between 3.9 – 62.5 μg/mL. Further, compounds 12d, 12g and 12l exhibit promising antifungal activity with MIC values ranging between 7.8 – 32.5 μg/mL. Further studies are underway for determining the antifungal molecular mechanisms of these potential compounds.

中文翻译：

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苯并噻唑连接异恶唑席夫碱的合成及抗菌评价

已经制备了一系列新的苯并噻唑连接的异恶唑席夫碱衍生物，并通过合适的光谱方法通过 1H 和 13C NMR、ESI-MS 和 IR 光谱对其进行了表征。已经进一步筛选了这些化合物对一组微生物的抗微生物活性。其中，化合物 12d、12g 和 12l 显示出对所有测试菌株的有希望的抗菌活性，MIC 值范围在 3.9 – 62.5 μg/mL 之间。此外，化合物 12d、12g 和 12l 表现出有希望的抗真菌活性，MIC 值范围为 7.8 – 32.5 μg/mL。正在进行进一步的研究以确定这些潜在化合物的抗真菌分子机制。