Abstract

We conceived a novel hybrid carrier of a thermal-responsive molecularly imprinted polymer (MIP) and a magnetic thermal seed (MTS) that showed a heat-generating ability under an alternate current (AC) magnetic field. Compared to our previous publications, we modify both the MIP and MTS to improve the feasibility for the hybrid carrier, briefly we have to achieve the accurate size control and narrower size distribution of MTS, and higher molecular recognition/release ability of MIP. Firstly, uniformly sized particles which are expected to show a large heat-generating ability under an AC magnetic field were successfully prepared by controlling the core creation. Then, an MIP targeted for selective adsorption of pemetrexed (PMX), a well-known anti-cancer drug, was prepared using N-carbobenzoxy-l-glutamic acid as a pseudo template. Finally, the preliminary hybridization of the MTS and the MIP-equivalent polymer coating was examined by introducing vinyl groups as methacrylic acid using a ligand exchanging method.

摘要

我们构思了一种由热响应分子印迹聚合物 (MIP) 和磁热种子 (MTS) 组成的新型混合载体，该载体在交流 (AC) 磁场下显示出发热能力。与我们之前的出版物相比，我们修改了 MIP 和 MTS 以提高混合载体的可行性，简而言之，我们必须实现 MTS 的准确尺寸控制和更窄的尺寸分布，以及 MIP 更高的分子识别/释放能力。首先，通过控制核的产生，成功制备了尺寸均匀的颗粒，这些颗粒有望在交流磁场下显示出较大的发热能力。然后，使用N- carbobenzoxy- l制备了一种靶向选择性吸附培美曲塞 (PMX)（一种众所周知的抗癌药物）的MIP。-谷氨酸作为伪模板。最后，通过使用配体交换方法引入乙烯基作为甲基丙烯酸来检查 MTS 和 MIP 等效聚合物涂层的初步杂交。