Introduction: The augmentation index (AIx) or central systolic blood pressure (SBP), measured by radial applanation tonometry, has been reported to be independently associated with left ventricular hypertrophy (LVH) in Japanese hypertensive patients. Cuff-based oscillometric measurement of the AIx using Mobil-O-Graph® showed a low or moderate agreement with the AIx measurement with other devices. Methods: The AIx measured using the Mobil-O-Graph was validated against the tonometric measurements of the radial AIx measured using HEM-9000AI in 110 normotensive healthy individuals (age, 21–76 years; 50 men). We investigated the relationship between the central hemodynamics assessed using the Mobil-O-Graph and LVH in 100 hypertensive patients (age, 54–75 years; 48 men), presenting a wall thickness of ≥11 mm and ≥10 mm in men and women, respectively. Results: Although the Mobil-O-Graph-measured central AIx showed no negative values, it correlated moderately with the HEM-9000AI-measured radial AIx (r = 0.602, p #x3c; 0.001) in the normotensive individuals. The hypertensive patients did not show a significant difference in the central SBP between the sexes, but the central AIx was lower in men than in women. The independent determinants influencing left ventricle (LV) mass index (LVMI) (R² = 0.362; adjusted R² = 0.329, p #x3c; 0.001) were heart rate (β = −0.568 ± 0.149, p #x3c; 0.001), central SBP (β = 0.290 ± 0.100, p = 0.005), and aortic root diameter (β = 1.355 ± 0.344, p = 0.001). Age (β = −0.025 ± 0.124, p = 0.841) and the central AIx (β = 0.120 ± 0.131, p = 0.361) were not independently associated with the LVMI. The area under the receiver operator characteristic curve to evaluate the diagnostic performance of the central AIx for the presence of LVH (LVMI #x3e;118 g/m² in men or #x3e;108 g/m² in women) was statistically significant in men (0.875, p #x3c; 0.001) but not in women (0.622, p = 0.132). In men, a central AIx of 28.06% had a sensitivity of 83.3% and specificity of 80.0% for detecting LVH. Conclusions: AIx measurement in men provided useful prognostic information for the presence of LVH. Pulse-wave analysis assessed using the Mobil-O-Graph may be a valuable tool for detecting LVH in hypertensive patients.
Pulse

中文翻译：

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高血压患者中枢血流动力学示波测量与左心室肥厚的关系

简介：据报道，通过径向压平眼压计测量的增强指数 (AIx) 或中心收缩压 (SBP) 与日本高血压患者的左心室肥厚 (LVH) 独立相关。使用 Mobil-O-Graph® 对 AIx 进行基于袖带的示波测量显示与使用其他设备的 AIx 测量结果的一致性较低或中等。方法：使用 Mobil-O-Graph 测量的 AIx 与使用 HEM-9000AI 在 110 名血压正常的健康个体（年龄，21-76 岁；50 名男性）中测量的径向 AIx 的眼压测量值进行了验证。我们调查了 100 名高血压患者（年龄 54-75 岁；48 名男性）使用 Mobil-O-Graph 评估的中心血流动力学与 LVH 之间的关系，男性和女性的壁厚分别为 ≥11 mm 和 ≥10 mm ， 分别。结果：虽然 Mobil-O-Graph 测量的中心 AIx 没有显示负值，但它与 HEM-9000AI 测量的径向 AIx 有中度相关（r = 0.602，p#x3c; 0.001) 在血压正常的个体中。高血压患者的中枢收缩压在两性之间没有显着差异，但男性的中枢 AIx 低于女性。影响左心室 (LV) 质量指数 (LVMI) 的独立决定因素（R ² = 0.362；调整后的R ² = 0.329，p #x3c；0.001）是心率（β = -0.568 ± 0.149，p #x3c；0.001），中央 SBP (β = 0.290 ± 0.100, p = 0.005) 和主动脉根部直径 (β = 1.355 ± 0.344, p = 0.001)。年龄 (β = -0.025 ± 0.124, p = 0.841) 和中央 AIx (β = 0.120 ± 0.131, p= 0.361) 与 LVMI 没有独立关联。受试者操作特征曲线下面积用于评估中央 AIx 对 LVH 的诊断性能（LVMI #x3e；男性为 118 g/m ²或女性为 #x3e；108 g/m ²）具有统计学意义。男性（0.875，p #x3c；0.001），但女性没有（0.622，p = 0.132）。在男性中，28.06% 的中央 AIx 检测 LVH 的敏感性为 83.3%，特异性为 80.0%。结论：男性的 AIx 测量为 LVH 的存在提供了有用的预后信息。使用 Mobil-O-Graph 评估的脉搏波分析可能是检测高血压患者 LVH 的宝贵工具。
脉冲