Abstract

Autologous conditioned serum (ACS) is a blood-derived product that is prepared by the incubation of whole blood with medical-grade glass beads, resulting in serum enrichment in interleukin-1 receptor antagonist (IL-1Ra), anti-inflammatory cytokines (IL-4, IL-10, and IL-13), and high concentrations of growth factors. ACS has shown qualitatively and quantitatively better therapeutic effects than most established pharmacological treatments and surgery for joint diseases given its ability to both target the inflammatory cascade to decrease cartilage destruction as well as improve endogenous repair mechanisms. ACS application is simple and safe with limited adverse effects. This article reviews the role of ACS in degenerative joint disease, in addition to other inflammatory and autoimmune diseases, given its regenerative and immune-modulating properties.

摘要

自体条件血清 (ACS) 是一种血液衍生产品，通过将全血与医用级玻璃珠孵育，导致血清富集白介素-1 受体拮抗剂 (IL-1Ra)、抗炎细胞因子 (IL -4、IL-10 和 IL-13)，以及高浓度的生长因子。ACS 已显示出比大多数已建立的关节疾病药物治疗和手术在质量和数量上更好的治疗效果，因为它既能靶向炎症级联反应以减少软骨破坏，又能改善内源性修复机制。ACS 应用简单安全，副作用有限。本文回顾了 ACS 在退行性关节病以及其他炎症和自身免疫性疾病中的作用，