A series of quinoline incorporated 2,4,5-trisubstituted imidazole derivatives (4a-h and 5a-f) have been synthesized. The structures of the synthesized compounds have been established by FT-IR, 1H NMR and mass spectral analysis. The prepared compounds have been evaluated for their in vitro antioxidant activity by DPPH method and antibacterial activity against Bacillus subtilis, Escherichia coli, Bacillus megaterium and Salmonella typhi bacterial strains at 500 µg/mL concentration. The compounds 4a, 4e and 4d exhibit good antioxidant activity. Among the synthesized compounds, 4a has shown significant antibacterial activity against all the three tested microorganisms.

中文翻译：

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喹啉掺入2,4,5三取代咪唑衍生物的合成、抗氧化和抗菌活性

已经合成了一系列喹啉并入的 2,4,5-三取代咪唑衍生物（4a-h 和 5a-f）。合成化合物的结构已通过FT-IR、1H NMR和质谱分析确定。已通过 DPPH 方法评估了制备的化合物的体外抗氧化活性和对枯草芽孢杆菌、大肠杆菌、巨大芽孢杆菌和伤寒沙门氏菌菌株的抗菌活性，浓度为 500 µg/mL。化合物4a、4e和4d表现出良好的抗氧化活性。在合成的化合物中，4a 对所有三种测试微生物都显示出显着的抗菌活性。