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Mixed ligand complex of monovalent copper with benzimidazole derivatives and alanine: Synthesis, characterization and antimicrobial studies
Indian Journal of Chemistry, Section A ( IF 0.412 ) Pub Date : 2021-12-16
Poonam Yadav, Shobhana Sharma, Suman Kumari, Seema, Mamta Ranka

xed ligand complexes of transition metal ions exhibit broad range of biological activities. Schiff bases containing azomethine (C=N) group and amino acids are versatile compounds for design of ternary complexes. An attempt has been made to synthesize novel copper(I) complex by the reaction of two ligands, 2-N-(4-methyl phenyl ethanimine) benzimidazole [MPEIBI] as L1 and an amino acid Alanine as L2, and freshly prepared cuprous chloride solution in 1:1:1 molar ratio through conventional reflux method. The synthesized ligand and copper(I) complex are characterized by elemental analysis, molecular weight determination, magnetic moment measurement, spectroscopic techniques. These synthesized compounds were evaluated for antimicrobial studies against bacterial strains, B. subtilis, E. coli and fungal pathogens, T. ressei, C. albicans. The Cu(I) complex has shown remarkable antibacterial and antifungal activity.

中文翻译:

一价铜与苯并咪唑衍生物和丙氨酸的混合配体络合物:合成、表征和抗菌研究

过渡金属离子的固定配体配合物表现出广泛的生物活性。含有偶氮甲碱 (C=N) 基团和氨基酸的席夫碱是用于设计三元配合物的通用化合物。已尝试通过两个配体,2-N-(4-甲基苯基乙胺)苯并咪唑 [MPEIBI] 作为 L1 和氨基酸丙氨酸作为 L2 和新鲜制备的氯化亚铜反应合成新型铜(I)配合物通过常规回流方法以1:1:1的摩尔比溶解。合成的配体和铜(I)配合物通过元素分析、分子量测定、磁矩测量、光谱技术表征。这些合成的化合物被评估用于针对细菌菌株、枯草芽孢杆菌、大肠杆菌和真菌病原体、T. ressei、C. albicans 的抗菌研究。
更新日期:2021-12-16
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