When navigating through space, we must maintain a representation of our position in real time; when recalling a past episode, a memory can come back in a flash. Interestingly, the brain's spatial representation system, including the hippocampus, supports these two distinct timescale functions. How are neural representations of space used in the service of both real-world navigation and internal mnemonic processes? Recent progress has identified sequences of hippocampal place cells, evolving at multiple timescales in accordance with either navigational behaviors or internal oscillations, that underlie these functions. We review experimental findings on experience-dependent modulation of these sequential representations and consider how they link real-world navigation to time-compressed memories. We further discuss recent work suggesting the prevalence of these sequences beyond hippocampus and propose that these multiple-timescale mechanisms may represent a general algorithm for organizing cell assemblies, potentially unifying the dual roles of the spatial representation system in memory and navigation.

中文翻译：

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空间的多时间尺度表示：将记忆与导航联系起来。

在空间中导航时，我们必须实时保持我们位置的表示；当回忆起过去的情节时，记忆会在一瞬间浮现出来。有趣的是，大脑的空间表征系统（包括海马体）支持这两种不同的时间尺度功能。空间的神经表征如何用于现实世界导航和内部记忆过程？最近的进展已经确定了海马位置细胞的序列，这些序列根据导航行为或内部振荡在多个时间尺度上进化，这是这些功能的基础。我们回顾了这些顺序表示的依赖于经验的调制的实验结果，并考虑它们如何将现实世界的导航与时间压缩的记忆联系起来。