The retromer complex is an evolutionarily conserved protein complex involved in the endosomal recycling of various cargo proteins. It is ubiquitously expressed in all tissue and is found in both invertebrate as well as mammalian nervous systems, where it recycles various synaptic membrane proteins including the dopamine transporter and dopamine D1 receptor, two proteins implicated in dopamine homeostasis and neurotransmission. The involvement of the retromer complex in dopamine neurobiology is further underscored by its links to Parkinson's disease, a neurodegenerative disorder of the dopamine system. In this article, the existing literature linking the retromer complex to synaptic function and dopamine homeostasis is reviewed. Additional possible links are highlighted by exploring the retromer and other Parkinson's disease-associated proteins and possible relationships to synaptic function and dopamine transmission.

中文翻译：

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内体循环和多巴胺神经传递：探索逆转录酶与帕金森病之间的联系

逆转录酶复合物是一种进化上保守的蛋白质复合物，参与各种货物蛋白的内体循环。它在所有组织中普遍表达，在无脊椎动物和哺乳动物神经系统中都存在，在那里它回收各种突触膜蛋白，包括多巴胺转运蛋白和多巴胺 D1 受体，这两种蛋白与多巴胺稳态和神经传递有关。逆转录酶复合物在多巴胺神经生物学中的参与进一步强调了它与帕金森病的联系，帕金森病是一种多巴胺系统的神经退行性疾病。本文回顾了将逆转录复合体与突触功能和多巴胺稳态联系起来的现有文献。通过探索逆转录酶和其他帕金森氏症，突出显示了其他可能的链接