Pomegranate powder derived from pomegranate fruit contains phytochemicals chief of which is ellagitannins. Owing to their high antioxidative capabilities we investigated its efficacy against lead acetate induced hepatic and renal toxicity. Pomegranate powder (500 g) was procured and soaked in 1 Litre of ethanol for three days, its filtrate was concentrated and freeze dried to form Punica granatum L. ethanol extract (PLEE). Thirty (30) male albino Wistar rats with average weight between 140 ± 20 g were used for this study. They were equally shared into 6 groups with 5 animals each; A: Control; B: Lead acetate only C: Lead acetate + PLEE (1); D: Lead acetate + PLEE (2); E: PLEE (1) and F: PLEE (2). Serum, liver and kidney samples were obtained for biochemical assays. The integrity of liver and kidney tissues were also accessed. Lead administration resulted in marked elevations in liver transaminases in serum and liver as well as a significant increase in kidney function markers in the serum and kidney (p < 0.05). There was also a significant decline in average body weight, antioxidant markers in the liver and kidney of Wistar rats while there was a significant increase in lipid peroxidation levels in both liver and kidney. However, administration of PLEE at different doses significantly modulated these changes. Lead acetate administration led to hepatic and renal toxicity as evident by alterations in liver and kidney function markers, antioxidant status and tissue integrity. However, PLEE can combat these toxicities.

中文翻译：

---

石榴粉末乙醇提取物 (PLEE) 对醋酸铅肝肾毒性的调节作用

从石榴果实中提取的石榴粉含有植物化学物质，其中主要是鞣花单宁。由于它们的高抗氧化能力，我们研究了它对醋酸铅诱导的肝和肾毒性的功效。取石榴粉(500g)，在1L乙醇中浸泡3天，将滤液浓缩，冷冻干燥，形成石榴乙醇提取物(PLEE)。本研究使用了三十 (30) 只平均体重在 140 ± 20 克之间的雄性白化病 Wistar 大鼠。平均分成6组，每组5只；A：控制；B：仅醋酸铅 C：醋酸铅 + PLEE (1)；D：醋酸铅+PLEE（2）；E：PLEE (1) 和 F：PLEE (2)。获得血清、肝脏和肾脏样本用于生化分析。还访问了肝脏和肾脏组织的完整性。铅给药导致血清和肝脏中的肝转氨酶显着升高，以及血清和肾脏中的肾功能标志物显着增加（p < 0.05）。Wistar 大鼠的平均体重、肝脏和肾脏中的抗氧化标志物也显着下降，而肝脏和肾脏中的脂质过氧化水平显着增加。然而，不同剂量的PLEE给药显着调节了这些变化。醋酸铅给药导致肝肾毒性，肝肾功能标志物、抗氧化状态和组织完整性的改变就证明了这一点。然而，PLEE 可以对抗这些毒性。