Calprotectin is one of the most abundant proteins of neutrophil granulocytes. It is released upon neutrophil activation and is considered a sensitive and clinically useful marker for neutrophil-mediated inflammation, including bacterial infections. However, early kinetics of calprotectin activation following inflammatory activation has hitherto been unknown. The aim of the present study was to determine the early phase of the kinetics of calprotectin, in comparison with the inflammatory markers CRP, IL-6, TNF-α, and procalcitonin, in plasma following a standardized temporary mild inflammatory response, using uncomplicated inguinal hernia surgery as a model. The study cohort consisted of 17 adult patients (15 male and 2 female) undergoing elective surgery for hernia. Values of calprotectin increased significantly at 2 h following surgery, and continued to increase to reach the highest level at 24–36 h after surgery, values still not exceeding upper normal reference level. This contrasts to IL-6 and CRP, for which an elevation was found first later, 4 h and 24–36 h post-surgery, respectively, for IL-6, and CRP. No significant increase was seen for TNF-α, or procalcitonin. The data demonstrate a very rapid and significant but modest increase in calprotectin following induction of mild inflammation, supporting that calprotectin can be useful for early detection of inflammatory response.

钙卫蛋白是中性粒细胞中最丰富的蛋白质之一。它在中性粒细胞激活时释放，被认为是中性粒细胞介导的炎症（包括细菌感染）的敏感且临床有用的标志物。然而，迄今为止，炎症激活后钙卫蛋白激活的早期动力学仍是未知的。本研究的目的是确定钙卫蛋白动力学的早期阶段，与炎症标志物 CRP、IL-6、TNF-α 和降钙素原相比，在标准化的暂时性轻度炎症反应后，使用简单的腹股沟疝气手术作为模型。研究队列由 17 名接受疝气择期手术的成年患者（15 名男性和 2 名女性）组成。术后 2 小时钙卫蛋白值显着增加，并在术后 24～36 h 持续升高至最高值，仍不超过正常参考值上限。这与 IL-6 和 CRP 形成对比，IL-6 和 CRP 分别在术后 4 小时和 24-36 小时发现升高。TNF-α或降钙素原未见显着增加。数据表明，在诱导轻度炎症后，钙卫蛋白会非常快速且显着但适度增加，这支持了钙卫蛋白可用于早期检测炎症反应。TNF-α或降钙素原未见显着增加。数据表明，在诱导轻度炎症后，钙卫蛋白会非常快速且显着但适度增加，这支持了钙卫蛋白可用于早期检测炎症反应。TNF-α或降钙素原未见显着增加。数据表明，在诱导轻度炎症后，钙卫蛋白会非常快速且显着但适度增加，这支持了钙卫蛋白可用于早期检测炎症反应。