Introduction. The coronavirus disease 2019 (COVID-19), that is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has spread rapidly worldwide since December 2019. The SARS-CoV-2 virus has a great affinity for the angiotensin-converting enzyme-2 (ACE-2) receptor, which is an essential element of the renin-angiotensin system (RAS). This study is aimed at assessing the impact of the angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphisms, on the susceptibility and clinical outcomes of the COVID-19 immunoinflammatory syndrome. Patients and Methods. A total of 112 patients diagnosed with COVID-19 between 1 and 15 May 2020 were enrolled in the study. ACE gene allele frequencies were compared to the previously reported Turkish population comprised of 300 people. Results. The most common genotype in the patients and control group was DI with 53% and II with 42%, respectively. The difference in the presence of the D allele between the patient and control groups was statistically significant (67% vs. 42%, respectively, ). Severe pneumonia was observed more in patients with DI allele (31%) than DD (8%) and II (0%) (). The mortality rate, time to defervescence, and the hospitalization duration were not different between the genotype groups. Conclusion. Genotype DI of ACE I/D polymorphism is associated with the infectious rate particularly severe pneumonia in this study conducted in the Turkish population. Therefore, ACE D/I polymorphism could affect the clinical course of COVID-19.

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人类 Ace D/I 多态性可能影响 COVID-19 的临床生物学过程

简介。由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引起的 2019 年冠状病毒病 (COVID-19) 自 2019 年 12 月以来在全球范围内迅速传播。SARS-CoV-2 病毒对血管紧张素转换酶 2 (ACE-2) 受体，它是肾素-血管紧张素系统 (RAS) 的重要组成部分。本研究旨在评估血管紧张素转换酶 (ACE) 基因插入 (I)/缺失 (D) 多态性对 COVID-19 免疫炎症综合征的易感性和临床结果的影响。患者和方法. 在 2020 年 5 月 1 日至 15 日期间，共有 112 名诊断为 COVID-19 的患者参加了该研究。将 ACE 基因等位基因频率与先前报道的 300 人的土耳其人口进行了比较。结果。患者和对照组最常见的基因型分别为 DI 和 42% 的 DI 和 42%。患者组和对照组之间存在 D 等位基因的差异具有统计学意义（分别为 67% 和 42%，）。DI 等位基因患者（31%）比 DD（8%）和 II（0%）患者更多地观察到重症肺炎（）。基因型组之间的死亡率、退热时间和住院时间没有差异。结论。在土耳其人群中进行的这项研究中，ACE I/D 多态性的基因型 DI 与感染率特别是严重的肺炎有关。因此，ACE D/I 多态性可能会影响 COVID-19 的临床过程。