Objective. Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS). Methods and Results. Plasma Ang-III and APA levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 44 normal subjects and 84 patients confirmed as having CAS by coronary angiography. Circulating Ang-III levels were significantly lower in patients with CAS than in normal controls (). APA levels were slightly lower in the CAS group (). According to the severity of atherosclerosis, CAS patients were divided into two groups. Compared with the controls, the APA and Ang-III levels were lower in the high scoring group and APA decreased significantly. Conclusions. Circulating Ang-III levels were reduced in patients with CAS, and the possible reason may be related to the decrease in the APA level.

中文翻译：

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冠状动脉粥样硬化患者循环血管紧张素Ⅲ水平及意义

客观。血管紧张素-III (Ang-III) 是由氨肽酶 A (APA) 代谢的血管紧张素-II (Ang-II) 的下游产物。目前，Ang-III的研究主要集中在高血压和中枢肾素-血管紧张素系统（RAS）方面。然而，很少有研究关注 Ang-III 与冠状动脉粥样硬化 (CAS) 之间的关系。方法和结果。通过酶联免疫吸附试验 (ELISA) 在 44 名正常受试者和 84 名冠状动脉造影证实患有 CAS 的患者中测量血浆 Ang-III 和 APA 水平。CAS 患者的循环 Ang-III 水平显着低于正常对照组（）。CAS 组的 APA 水平略低（）。根据动脉粥样硬化的严重程度，将CAS患者分为两组。与对照组相比，高分组APA和Ang-III水平较低，APA明显下降。结论。CAS患者循环Ang-III水平降低，可能的原因可能与APA水平降低有关。