ABSTRACT

The combination of membranes and microfluidic systems has been applied in areas such as bioscience, environmental and analytical chemistry, and in the past time research into the integration of membrane mass transfer control functions into microfluidic devices has shown a significant growth trend. The multiple uses of membrane-based microfluidic systems have been demonstrated in published reports. The aim of this paper is to provide an overview of the development process in this field, starting with the basic terminology of microfluidic and membrane processes and outlining membrane-based microfluidic platforms that combine the two, followed by a classification of membrane integration on a chip based on the preparation methods used to combine the two. Three membrane functions that membranes can perform in microfluidic systems are then discussed; they are separation and enrichment of substances, immobilization and culturing of cells, and fluid control of pumps and valves. Finally, several possible research directions and related issues for membrane-based microfluidic platforms are presented, providing a deeper reference for future research combining membranes with microfluidic platforms.

摘要

膜与微流控系统的结合已应用于生物科学、环境和分析化学等领域，过去将膜传质控制功能集成到微流控装置中的研究显​​示出显着的增长趋势。已发表的报告证明了基于膜的微流体系统的多种用途。本文的目的是概述该领域的发展过程，从微流体和膜过程的基本术语开始，概述将两者结合的基于膜的微流体平台，然后是芯片上膜集成的分类基于用于将两者结合的制备方法。然后讨论了膜在微流体系统中可以执行的三种膜功能；它们是物质的分离和富集，细胞的固定和培养，以及泵和阀门的流体控制。最后，提出了基于膜的微流控平台的几个可能的研究方向和相关问题，为未来膜与微流控平台结合的研究提供更深层次的参考。